Chemistry

Unraveling the science behind Curcumin C3 Reduct®

Tetrahydrocurcuminoids (THCs) are the major active metabolites of curcumin that are formed in the body upon oral or peritoneal administration.

Structurally, the Tetrahydrocurcumin (THC) is similar to curcumin with saturated double bonds of heptadiene chain between two aryl groups present in curcumin.

The other curcuminoids, namely demethoxycurcumin and bisdemethoxycurcumin also give rise to the more saturated derivatives – Tetrahydrodemethoxycurcumin (THDMC) and Tetrahydrobisdemethoxycurcumin (THBDMC), respectively.

The THCs have been isolated as a natural product from Zingiber officinale (ginger).

The minor constituents THDMC and THBDMC also occur naturally in Curcuma zeodaria, a Thai plant known for its anti-inflammatory activity in Thai traditional medicine system.

Tetrahydrocurcumin (THC)

Tetrahydrodemethoxycurcumin (THDMC)

Tetrahydrobisdemethoxycurcumin (THBDMC)